Although more elaborated methods for calculation of coordinate pairs x 3, y 3 are conceivable to account for non-linearly distorted figures (by scanning), our approach allows for rotation and linear skewness and is straightforward to implement into a C programme. The assumption that k α a → and k β b → are always parallel to the y and x axis is simple. In the present paper, we describe the functionality and the interface of the programme, compare it with those of other publically available tools and provide a quick introduction to its use on the basis of example figures. Since we believe that our tool is helpful especially for other research groups interested in dynamical modelling or meta-analyses, we aim at publishing it as an open source and freely available software. Time series data of numerous blood parameters are required for parameterisation and validation of our models of human thrombopoiesis, erythropoiesis, granulopoiesis under chemotherapy and growth-factor applications and for other models currently under development. The development of ycasd was motivated by our own work in the field of modelling blood formation. For a typical example see Additional file 1. The problem of skewed diagrams obtained from scanning papers is also addressed. To support this task, we developed the tool ycasd ( y casd captures and scales data) which can capture data from many kinds of graphical representations. In order to include these data into environments used for model simulations, it is necessary to extract them from the presentations chosen in the literature. This especially applies for systems-biological modelling for which time series data under different clinical conditions are required to calibrate the models and to validate their predictions. However, incorporating these data in research projects is often necessary to compare one’s own results with those of the literature. In medical literature, data of other groups are often not available in their raw formats but are presented in figures such as scatter plots, box plots, time series data or derived statistics such as Kaplan-Meier curves.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |